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| 10 October 2010 Ballina RFC | ||||
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12:00 pm | Connemara | at Ballina | |
| 10 October 2010 Ballinasloe R.F.C. | ||||
|
12:00 pm | Galwegians (Sat Only) | at Ballinasloe (Sat only) | |
| 10 October 2010 Corinthian Park, Galway | ||||
|
12:00 pm | Creggs | at Corinthians | |
| 10 October 2010 Dubarry Park, Athlone | ||||
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12:00 pm | Monivae | at Buccaneers | |
| 10 October 2010 Sligo R.F.C. | ||||
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12:00 pm | Ballaghaderreen | at Sligo | |
| 10 October 2010 Westport R.F.C. | ||||
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12:00 pm | Castlebar | at Westport | |
| 17 October 2010 Ballaghderreen RFC | ||||
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12:00 pm | Westport | at Ballaghaderreen | |
| 17 October 2010 Castlebar RFC | ||||
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12:00 pm | Ballina | at Castlebar | |
| 17 October 2010 Connemara RFC | ||||
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12:00 pm | Sligo | at Connemara | |
| 17 October 2010 Creggs R.F.C. | ||||
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12:00 pm | Ballinasloe (Sat only) | at Creggs | |
| 17 October 2010 Galwegians R.F.C. | ||||
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12:00 pm | Buccaneers | at Galwegians (Sat Only) | |
| 17 October 2010 Monivae R.F.C. | ||||
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12:00 pm | Corinthians | at Monivae | |
| 24 October 2010 Ballaghderreen RFC | ||||
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12:00 pm | Connemara | at Ballaghaderreen | |
| 24 October 2010 Corinthian Park, Galway | ||||
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12:00 pm | Ballinasloe (Sat only) | at Corinthians | |
| 24 October 2010 Dubarry Park, Athlone | ||||
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12:00 pm | Creggs | at Buccaneers | |
| 24 October 2010 Monivae R.F.C. | ||||
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12:00 pm | Galwegians (Sat Only) | at Monivae | |
| 24 October 2010 Sligo R.F.C. | ||||
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12:00 pm | Castlebar | at Sligo | |
| 24 October 2010 Westport R.F.C. | ||||
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12:00 pm | Ballina | at Westport | |
| 07 November 2010 Ballina RFC | ||||
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12:00 pm | Sligo | at Ballina | |
| 07 November 2010 Ballinasloe R.F.C. | ||||
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12:00 pm | Buccaneers | at Ballinasloe (Sat only) | |
| 07 November 2010 Castlebar RFC | ||||
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12:00 pm | Ballaghaderreen | at Castlebar | |
| 07 November 2010 Connemara RFC | ||||
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12:00 pm | Westport | at Connemara | |
| 07 November 2010 Creggs R.F.C. | ||||
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12:00 pm | Monivae | at Creggs | |
| 07 November 2010 Galwegians R.F.C. | ||||
|
12:00 pm | Corinthians | at Galwegians (Sat Only) | |
| 14 November 2010 Ballaghderreen RFC | ||||
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12:00 pm | Ballina | at Ballaghaderreen | |
| 14 November 2010 Connemara RFC | ||||
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12:00 pm | Castlebar | at Connemara | |
| 14 November 2010 Corinthian Park, Galway | ||||
|
12:00 pm | Buccaneers | at Corinthians | |
| 14 November 2010 Galwegians R.F.C. | ||||
|
12:00 pm | Creggs | at Galwegians (Sat Only) | |
| 14 November 2010 Monivae R.F.C. | ||||
|
12:00 pm | Ballinasloe (Sat only) | at Monivae | |
| 14 November 2010 Westport R.F.C. | ||||
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12:00 pm | Sligo | at Westport | |